Isaac Wasserman

Diagnostle

Daily Medical Diagnosis Game

2026

diagnostle.com

Diagnostle is a daily puzzle for medical professionals, hobbyists, and hypocondriacs alike.

Each day, you’re presented with a patient’s chief complaint. Your job is to diagnose the patient through a series of tests and educated guesses.

On each turn you can either run a test or guess a diagnosis. Tests allow you to gather clues through labs, imaging, or physical exams, while guessing a diagnosis will offer feedback on whether you’re in the right ballpark in terms of organ system or severity.

Compete with your friends to see who can arrive at the correct diagnosis in the fewest turns.

Example Differential Diagnosis
Example Differential Diagnosis